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Effect of pirimiphos-methyl, an organophosphorus insecticide on hematological parameters in albino rats.

Rajini, P S; Viswanatha, S; Krishnakumari, M K.

Indian J Exp Biol ; 1987 Mar; 25(3): 190-3

Article in English | IMSEAR | ID: sea-62596

Subject(s)

Animals , Blood Coagulation/drug effects , Erythrocyte Count/drug effects , Insecticides/toxicity , Leukocyte Count/drug effects , Male , Organothiophosphorus Compounds/toxicity , Rats , Rats, Inbred Strains

Cardiotoxic effects of dichlorvos (DDVP) in albino rats.

Naidu, K A; Viswanatha, S; Krishnakumari, M K.

Indian J Physiol Pharmacol ; 1987 Jan-Mar; 31(1): 19-24

Article in English | IMSEAR | ID: sea-108560

ABSTRACT

Dichlorvos (O, O-dimethyl O-(2,2-dichlorovinyl phosphate: DDVP 76.6 X EC) an organophosphate pesticide had a profound effect on cardiac activity of albino rats. Adult male rats anesthetized with pentobarbitone were administered 30, 50, 70 and 90 mg/kg body weight of dichlorvos. The heart rate and electrocardiogram were monitored and acetylcholinesterase activity was measured in heart and brain. Dichlorvos produced abnormalities in ECG, decrease in heart rate, cardiac arrest and inhibition of cholinesterase activity. It is suggested that cardiotoxic effect of DDVP may be mediated by the accumulated acetylcholine as a result of cholinesterase inhibition.

Subject(s)

Animals , Cholinesterase Inhibitors , Dichlorvos/toxicity , Electrocardiography , Female , Heart/drug effects , Heart Arrest/chemically induced , Heart Rate/drug effects , Lethal Dose 50 , Male , Rats , Rats, Inbred Strains

Subject(s)

ABSTRACT

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